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Cyproterone acetate, a synthetic progestin with antiandrogenic activities (Neumann, 1968), was reported to have been used successfully in the treatment of male hypersexuality (Laschet & Laschet, 1968). The inhibition of sexuality reported in man, however, has not been found in rats (Zucker, 1966; Beach & Westbrook, 1968; Whalen & Edwards, 1969).

Chlormadinone acetate, a highly effective progestin, shows similar biological properties. In a comparative study both compounds were found to produce male hypogonadism in rats associated with maintenance of sexual activity. These substances were even capable of inducing sexual activity in prepubertally castrated males (Dörner, Götz & Mainz, 1971). In the present experiment the influence of chlormadinone acetate on both fertility and sexual behaviour was investigated simultaneously in normal male rats.

Male Sprague—Dawley rats were injected subcutaneously for 6 weeks with a daily dose of 10 mg chlormadinone acetate. Fertility and sexual behaviour were investigated during and after treatment. Tests