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Journal of Endocrinology (1972) 52, 189-196    DOI: 10.1677/joe.0.0520189
© 1972 Society for Endocrinology

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INACTIVATION OF LONG-ACTING THYROID STIMULATOR IN VIVO

B. R. SMITH and D. S. MUNRO

The prolonged action of long-acting thyroid stimulator (LATS) in the McKenzie assay could be related to the slow clearance of LATS from the blood of assay mice.

Injection of soluble thyroid extracts before or after LATS reduced the assay response. This corresponded with the inactivation of circulating LATS activity by the formation of a complex which was then rapidly removed from the blood.







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