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Lactogenesis was initiated by intraductal injection of prolactin into individual lobes of rabbit mammary glands previously developed by injections of oestrogen and progesterone. Nucleic acid metabolism was assessed at various times after prolactin treatment. A systemic pulse of [³H]thymidine or [³H]uridine was used to determine the specific effects of prolactin treatment on RNA and DNA synthesis and metabolism.

Prolactin increased the rate of RNA synthesis. It is suggested that prolactin enhanced both the rate of RNA movement from the nucleus, and its rate of metabolism in the cytoplasm. The greatest increase in the rate of synthesis occurred in non-ribosomal RNA. Subsequent to its effect on RNA, prolactin enhanced DNA synthesis. Total RNA per cell increased as indicated by an increased RNA:DNA ratio. These changes are considered to be specifically due to the local action of prolactin.

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				P. M. Schyve, F. Smithline, and H. Y. Meltzer Neuroleptic-induced Prolactin Level Elevation and Breast Cancer: An Emerging Clinical Issue Arch Gen Psychiatry, November 1, 1978; 35(11): 1291 - 1301. [Abstract] [PDF]