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It has been known for many years that milk secretion markedly decreases after adrenalectomy [see Cowie & Folley, 1947a]. Recent work indicates that the decrease in milk yield in the rat is due partly to metabolic effects of anorexia resulting from the operation, and partly to more direct effects of the loss of the adrenal hormones [Cowie & Folley, 1947b]. Folley & Cowie [1944] and Cowie & Folley [1947a] were able partially to restore lactation after adrenalectomy in their rats by administration of deoxycorticosterone acetate (doca). The mammary glands of such treated animals were noticeably heavier even than those of normal sham-operated controls which of course were lactating somewhat better. Since doca will cause growth of the mammary duct and alveolar systems [Van Heuverswyn, Folley & Gardner, 1939; Speert, 1940; Nelson, Gaunt & Schweizer, 1943; Mixner & Turner, 1942], it seemed possible that the increased weight of