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Phenothiazines elicit prolactin release both in vivo (Meites, Nicoll & Talwalker, 1963; Bryant, Connan & Greenwood, 1968) and in vitro (Danon, Dikstein & Sulman, 1963). Furthermore, they have a marked mammotrophic effect in the rat (Khazen, Mishkinsky, Ben-David & Sulman, 1968) and in the rabbit (Mishkinsky, Lajtos & Sulman, 1966). Perphenazine, a prototype phenothiazine, causes a sharp rise in plasma prolactin and gross udder development in the ewe (M. A. Saji, J. R. Delamere & G. E. Lamming, unpublished observations). Bearing in mind the possible lactogenic effect of perphenazine in farm animals, the present study was carried out in order to establish whether perphenazine stimulates mammary development and/or milk secretion in the ewe and whether the suspected higher prolactin levels are associated with a mammotrophic and/or a galactopoietic effect.

Mammary development. Sixteen 5-month-old Improved Awassi virgin ewes (Finci, 1957) (30 ± 2 kg body wt) were used to establish the