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Recently it was observed that in Rana temporaria interrenal activation was paralleled by a stimulation of both basophils type 3, located in the medio—rostro—ventral region of the distal lobe, and the caudal chromophobic cells (van Kemenade, 1969). Since chromophobes were identified as cells related to the different tinctorial cell types, and believed to be a stock of undifferentiated cells (Doerr-Schott, 1968), it was supposed that basophils type 3 were the source of corticotrophin (ACTH). For a more definite localization of the frog's corticotrophic function, basophils type 3 and caudal chromophobes were separated by dividing distal lobes into a rostral and a caudal half, each half then being tested for corticotrophic activity.

From 36 hibernating male frogs, pooled rostral and pooled caudal halves of the distal lobe were each homogenized in 18 ml distilled water, and stored at –20 °C. One week after operation, groups of pars distalis-ectomized frogs were injected