HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by OLSSON, K. Articles by McDONALD, I. R. Search for Related Content PubMed Articles by OLSSON, K. Articles by McDONALD, I. R.

When sheep or goats are given intrarumenal water loads of 100 ml/kg body wt they respond with a water diuresis beginning within 1 h and persisting for 3–4 h. Slow infusion of hypertonic NaCl solution into the third cerebral ventricle of goats causes prompt, transient and repeatable inhibition of such a water diuresis, due to the release of antidiuretic hormone (ADH) from the neurohypophysis (Andersson, Dallman & Olsson, 1969). However, intraventricular infusions of hypertonic sucrose are ineffective (Olsson, 1969). Because the latter observation appeared to be inconsistent with the osmoreceptor theory of the control of ADH release, it was desirable to test, in the ruminant animal, the classical observations made on the dog by Verney (1947). These observations demonstrated the antidiuretic effect of osmotic stimuli administered via the cerebral blood supply.

Two Clun Forest ewes were used. One (body wt 35 kg) had a left carotid artery loop, and the