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Some of the binding reactions between neurohypophysial hormones and protein are inhibited by calcium. This is true of binding with neurophysin (Smith & Thorn, 1965; Ginsburg, Jayasena & Thomas, 1966), with serum protein (Smith & Thorn, 1965) and of the uptake of vasopressin by kidney slices (Smith, 1963; Thorn & Willumsen, 1963a, b). The binding to neurophysin and to kidney protein and the uptake by the kidney appear to be dependent on a cysteinyl-free amino group, since deamino analogues of vasopressin and oxytocin are not bound or taken up (Stouffer, Hope & du Vigneaud, 1963; Chan, 1965; Ginsburg & Jayasena, 1968). One of the consequences of inhibition of binding to plasma protein by calcium appears to be the prolongation of the half-life of vasopressin in the circulation in rats (Smith & Thorn, 1965) and it seemed of interest, therefore, to investigate the effect of hypercalcaemia on the clearance of