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Fructose metabolism in the mammalian accessory sex organs is dependent on androgen (Mann, 1964). Fructose can be formed via either a phosphorylated or a nonphosphorylated metabolic pathway and several of the enzymes found in either of these pathways have been demonstrated to be dependent upon male sex hormone. Aldose reductase and ketose reductase are reduced after castration (Samuels, Harding & Mann, 1962); phosphatase (Stafford, Rubenstein & Meyer, 1949) and phosphofructokinase (Singhal, 1967) are similarly affected by androgens.

While fructose itself is readily lost from accessory sex structures after castration, less is known of the effects of androgen loss on the fructose phosphate esters such as fructose-6-phosphate (F-6-PO₄) or fructose-1,6-diphosphate (F-1,6-diPO₄). Fructose and fructose phosphate esters were therefore studied at short intervals after castration. Changes in the phosphatases were also investigated.

Tissues (anterior prostate or coagulating glands) were rapidly removed, frozen between sections of solid CO₂, weighed and