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The administration of a high-protein diet to rats, from the end of lactation until they reached a weight of 150 g., produced significant changes in the concentrations of insulin in the plasma and pancreas. Compared with controls, the animals receiving this diet had higher plasma glucose and insulin concentrations and a higher hormone content in the pancreas.

The levels of hepatic glycogen were similar to those in the control rats, but the muscle glycogen was significantly lower. Adipose tissue in vitro was less sensitive to the action of insulin on glucose uptake.