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Dopamine-containing neurons with cell bodies in the arcuate nucleus and axons projecting to the median eminence have been discovered (Fuxe & Hökfelt, 1967) and dopamine (DA) has been shown to evoke discharge of both luteinizing hormonereleasing factor (LRF) (Schneider & McCann, 1969a) and follicle-stimulating hormone-releasing factor (Kamberi, Schneider & McCann, 1969) from hypothalamic fragments incubated in vitro. Injection of DA into the third ventricle (3rd V) of rats increased plasma luteinizing hormone (LH) (Schneider & McCann, 1969b). The present experiments were performed to determine if stimulation of LH release in vivo was brought about by release of LRF.

Hypophysectomized rats were used since LRF has been detected in peripheral blood of hypophysectomized but not intact rats (Nallar & McCann, 1965). Stainless steel cannulae (22 gauge) were implanted into the 3rd V of hypophysectomized adult female Sprague—Dawley rats (Hormone Assay Lab., Chicago). One week or more after implantation of

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				R. Papeschi and D. J. McClure Homovanillic and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid of Depressed Patients Arch Gen Psychiatry, October 1, 1971; 25(4): 354 - 358. [Abstract] [PDF]