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This report concerns the tetrahydrometabolites of cortisol and corticosterone excreted as glucuronides in the urine of 20 normal children up to the age of 8 yr. There are numerous papers on the total urinary 17-hydroxycorticosteroid excretion in children, but few on the qualitative and quantitative fractionation of the individual urinary steroids (Guignard-De Maeyer, Crigler & Gold, 1963; Visser & Cost, 1964; Teller, 1967; Tanner & Gupta, 1968).

Our method, which incorporates several new features, has been adapted from those described by Birchall, Cathro, Forsyth & Mitchell (1963) and by Gupta (1965), the former having been used previously in this Department in a study of newborn infants. Assays are made on two consecutive pooled 24 hr. specimens of urine. After extraction and hydrolysis of the urinary conjugates both glucuronide and sulphate fractions are assayed separately, final separation of the individual steroids being achieved on paper using Bush systems (Bush, 1961). Any