HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by GIORGI, E. P. Articles by CROSIGNANI, P. G. Search for Related Content PubMed PubMed Citation Articles by GIORGI, E. P. Articles by CROSIGNANI, P. G.

Human plasma was dialysed against increasing concentrations of [4-¹⁴C]oestradiol-17β, [4-¹⁴C]oestrone, Na[6,7-³H]oestradiol-17β-glucuronide and Na[6,7-³H]oestrone sulphate. When the oestrogens were dialysed separately, binding to a protein with a limited number of binding sites (probably a globulin) could be shown. At comparable concentrations oestrone sulphate was bound to a greater extent than the free compounds and the glucuronide.

When free and conjugated oestrogens were dialysed together a displacement of the conjugates from globulin to albumin was demonstrated. This observation was confirmed by the results of the equilibrium dialysis of plasma of ovarian vein blood obtained from a mare and a donkey after injection of [4-¹⁴C]oestradiol-17β and Na[6,7-³H]oestradiol-177β-glucuronide into a Graafian follicle of the homolateral ovary. The possible physiological significance of this competition between free and conjugated oestrogens is discussed.