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Journal of Endocrinology (1969) 44, 139-172    DOI: 10.1677/joe.0.0440139
© 1969 Society for Endocrinology

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SOME ASPECTS OF CARBOHYDRATE METABOLISM IN PREGNANCY WITH SPECIAL REFERENCE TO THE ENERGY METABOLISM AND HORMONAL STATUS OF THE INFANT OF THE DIABETIC WOMAN AND THE DIABETOGENIC EFFECT OF PREGNANCY

JOYCE D. BAIRD

CONTENTS: Introduction

Effect on the foetus of diabetic diathesis in the mother

Size

Energy metabolism and hormonal status

Normal newborn infant

Infant of diabetic mother:

Blood glucose and free fatty acids

Hyperinsulinism

Hyperglycaemia

Growth hormone

Synalbumin antagonist

Adrenal cortex

Adrenal medulla

High perinatal mortality

Congenital abnormalities

Later incidence of clinical diabetes

The diabetogenic effect of pregnancy on the mother

Changes in glucose tolerance in normal pregnancy; criteria of normality; diagnosis of prediabetes

Plasma insulin in normal pregnancy

Glucose tolerance and plasma insulin in gestational diabetes

Parity and the development of diabetes

INTRODUCTION: The subject of pregnancy and diabetes can be considered from two main points of view: that of the baby and that of the mother.

There is no doubt that the children born to diabetic mothers (both before and after the development of clinical diabetes) commonly exceed the mean body weight for their gestational age, have a characteristic appearance,




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