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The steroid 11-oxygenation index (i.e. the ratio of the urinary metabolites of cortisol precursors to those of cortisol) has been used by Hill (1960) and by Edwards, Makin & Barratt (1964) in the diagnosis of congenital adrenal hyperplasia. Both showed that any circadian variations in the index were small compared with the gross abnormalities encountered in this condition. In the course of physiological studies on temperature and renal excretory circadian rhythms we have observed a small but definite circadian variation in the steroid 11-oxygenation index in normal men.

Six male subjects (ages ranging from 21 to 55 yr.) followed a routine consisting of rest, light activity, feeding and drinking, which was repeated every 90 min. during a 27 hr. experiment. Urine was collected for 3 hr. periods and the 11-deoxy and 11-oxy 17-hydroxycorticosteroids (11-deoxy and 11-oxy 17-OHCS) were separately estimated (Few, 1968) in each sample. The steroid 11-oxygenation index was