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An integral part of some current theories on regulation of the oestrous cycle is that increased secretion of oestrogen causes the pre-ovulatory release of luteinizing hormone (LH). The evidence in favour of this concept is, however, equivocal (see McCann, Dhariwal & Porter, 1968), a situation partly attributable to the inadequacy of methods used for the estimation of LH. In the sheep, the pre-ovulatory release of LH occurs during oestrus; this was inferred by Robertson & Hutchinson (1962) on the basis of pituitary content of LH, and was subsequently clearly demonstrated by Pelletier, Kann, Dolais & Rosselin (1968) and Wheatley & Radford (1969) using radioimmunoassay methods to estimate LH in plasma. The sensitivity of these latter methods provided a means of examining the role of ovarian steroids in the oestrous surge of LH in the ewe. This report deals with changes in plasma LH concentration following treatment of ovariectomized ewes with

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				J. Roberts and J. McCracken Prostaglandin F2alpha production by the brain during estrogen-induced secretion of luteinizing hormone Science, November 28, 1975; 190(4217): 894 - 896. [Abstract] [PDF]