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In a previous study, it was shown that thyroid hormone secretion rate (TSR) of female rats aged 55 days was reduced 22·8% by the s.c. injection of 50 µg. melatonin/day, by 14·8% when 75 µg./day was injected at 85 days, and by 9·1% when 100 µg./day was administered at 115 days (Narang, Singh & Turner, 1967). Since the rats were increasing in body weight during the period, the decrease in TSR with age may have been due to the effects of a lower dose of melatonin/g. body weight (Narang & Turner, 1966; Kumaresan & Turner, 1967). The object of the present experiment was to determine the effect of graded levels of melatonin upon the TSR of groups of rats of the same age and body weight and to determine whether melatonin has an effect on TSR of mature animals.

The TSR of 62 Sprague—Dawley—Rolfsmeyer female rats were estimated at 33