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In an investigation of the possible role of calcitonin in the metabolism of glycosaminoglycans it was found that the hormone increased the rate of disappearance from serum of [³⁵S]sulphate injected into rats. No excessive deposition of radioactive sulphate was found in bone, kidney, liver or ventricular myocardium of calcitonin-treated rats.

Calcitonin also rapidly lowered serum inorganic sulphate levels. Both effects were prevented by previous nephrectomy, leading to the conclusion that calcitonin acts on the kidney to promote the excretion of inorganic sulphate.