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The age at which cadmium salts first cause an increase in vascular permeability in the rat testis has been studied using Evans blue as a marker.

Cadmium-induced blueing of the testis, indicative of increased vascular permeability, first occurred on the 9th day of life, at about the same time as the descent of the testes and an apparent increase in the amount of 3β-hydroxysteroid dehydrogenase-positive tissue. The increased permeability coincided approximately with a rise in the alkaline phosphatase reactivity of the testicular capillary endothelium. It is suggested that the onset of sensitivity of the testicular blood vessels to cadmium salts is related in some way to the onset of androgen production by the testes.

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