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A pharmacological agent which could block the antidiuretic effect of antidiuretic hormone (ADH) would obviously have many uses. It could (a) be a diuretic with a new mechanism of action, (b) help in the diagnosis and possibly the treatment of the Schwartz-Bartter Syndrome (Thorn & Transbol, 1963) and ADH-secreting tumours (Ross, 1965) in the acute phase of inappropriate ADH secretion and hyponatremia, (c) elucidate the role of ADH in oedema, (d) be useful in the bioassay of ADH in body fluids to determine the specificity of the antidiuretic substance being measured. At present the only test for specificity commonly performed is incubation of the antidiuretic substance with sodium thioglycollate (Ames & van Dyke, 1951). If an ADH antagonist were available it could be administered to the assay rat and would block the effect produced by ADH alone thus indicating whether the antidiuretic substance assayed was ADH.

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