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Repeated exposures of intact rats, neurohypophysectomized rats and rats with denervated kidneys to high-pitched sound (20 kcyc./sec.) for 2 sec. with an intensity of 98–100 decibels caused diuresis, natriuresis and kaluresis: the rate of urinary excretion of adrenaline rose very significantly. Adrenal demedullation abolished the natriuresis and kaluresis in response to 20 kcyc./sec. and converted the diuresis to an antidiuresis. The renal response of normal rats to 20 kcyc./sec. was therefore attributed to the release of adrenaline from the adrenal medulla in amounts sufficient to prevent an emotional release of antidiuretic hormone from the neurohypophysis. Since 20 kcyc./sec. caused a significant increase in the urinary output of vasopressin by adrenalectomized rats, an emotional release of vasopressin is assumed to have proceeded, uninhibited, in adrenal-de-medullated rats exposed to 20 kcyc./sec., and to have caused the observed antidiuresis.

The diuresis, natriuresis and kaluresis caused by 150 cyc./sec. mimicked by s.c. injection of 4 m-u. oxytocin, was unaffected by demedullation of the adrenals and was not accompanied by increase in urinary adrenaline.