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Journal of Endocrinology (1968) 42, 27-32       DOI: 10.1677/joe.0.0420027
© 1968 Society for Endocrinology
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ACIDIC URINARY METABOLITES OF PROGESTERONE: STUDIES ON THE PREGNANT RABBIT

J. G. ALLEN and G. H. THOMAS

Indirect evidence is presented which suggests that the same acidic metabolites are obtained from the hydrolysed urine of the pregnant rabbit as from the non-pregnant animal injected with labelled progesterone. The acidic urinary metabolites were characterized by conversion with borohydridebismuthate to neutral aldehydes, which were then chromatographed on SE-30 and QF-1. In four rabbits the urinary excretion of the aldehydogenic metabolites and of pregnanediol, before and after mating, was parallel; the highest values were obtained in the 24 hr. after the coital stimulus.







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