HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by CAMERON, E. H. D. Articles by GRIFFITHS, K. Search for Related Content PubMed Articles by CAMERON, E. H. D. Articles by GRIFFITHS, K.

The removal of a large clear cell adenoma (67 g.) from a patient in the Cardiff Royal Infirmary presented an opportunity to investigate the relative importance of alternative metabolic pathways to cortisol in adrenal tissue consisting primarily of a single cell type. Experiments were performed in which chopped tumour tissue was incubated simultaneously with [4-¹⁴C]pregnenolone and [7-³H]progesterone for periods of time ranging from 5 to 120 min.

The conversion of these precursors to a variety of corticosteroids and intermediates was determined by radioisotope dilution techniques. From the results obtained, it was concluded that progesterone played only a minor role in the transformation of pregnenolone to cortisol in this tissue. It appeared that a large proportion of any progesterone formed from pregnenolone is rapidly metabolized to the 17-deoxycorticosteroids.