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The indicator fractionation principle (Sapirstein, 1958) has recently been used to measure blood flow changes in the testis and epididymis of the rat (Waites & Setchell, 1966). The validity of Sapirstein's principle has now been verified in the mouse by demonstrating that the ratio of isotope content of the brain, testis and epididymis to that in the rest of the body remains constant between 10 and 20 sec. after the intravenous injection of [4-¹³¹I]iodoantipyrine.

The present study was made to examine changes in the weight and relative blood flow of the testis and epididymis of the mouse at intervals after hypophysectomy. Mice of the Quackenbush strain, aged 8 weeks, were anaesthetized and about 10 µc of [4-¹³¹I]iodoantipyrine (Radiochemical Centre, Amersham) in 0·2 ml. 0·9% NaCl solution was injected into the lateral tail vein after warming the distal half of the tail to 40–43° Precisely 15 sec.