HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by HOPKINS, T. F. Articles by PINCUS, G. Search for Related Content PubMed Articles by HOPKINS, T. F. Articles by PINCUS, G.

The ovulatory response to pregnant mare serum gonadotrophin (PMS) was studied in immature rats bearing adenohypophysial (AP) and hypothalamic median eminence (ME) tissues grafted beneath the kidney capsule. A small piece of liver tissue only was grafted in control rats. PMS (30 i.u.) was administered subcutaneously to all rats on the fourth day after the grafts had been placed. The ovulatory response was depressed in all rats bearing AP tissue alone. Median eminence tissue transplanted from immature rats or from mature rats in various phases of the vaginal oestrous cycle had no effects on ovulation when transplanted alone. When present as a joint graft with AP tissue, pro-oestrous ME augmented the depressing effects on ovulation. In one series of experiments, the average number of ova in 29 liver tissue controls was 34·2 ± 9·6 with all the rats ovulating. The average number of ova in 24 rats bearing AP tissue was 19·7 ± 5·2 with 46% ovulating. In eight rats bearing AP plus early pro-oestrous ME, the average number of ova was 0·25 ± 0·25 with 12·5% ovulating. Augmentation of AP depressing effects was not apparent in rats bearing AP plus dioestrous or oestrous ME tissue. These results show that the ovulatory response to PMS is depressed by AP tissue grafted beneath the kidney capsule and suggests that pro-oestrous ME tissue grafted in close proximity to the AP tissue in some way augments the depressing effects.