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A subcellular fraction containing particles showing the characteristics of lysosomes has been isolated from the corpus luteum of the sheep. Histochemical and biochemical observations have demonstrated that the lysosomes increase in size and fragility late in the oestrous cycle. Similar changes were not found in the corpora lutea of pregnant animals.

The observed increase in lysosomal fragility is one of the earliest changes associated with luteal regression, and is thought to be of functional significance in the involution of the lutein cells.

The possible modification of lysosomal function by the production of a cell-specific lytic factor from the uterus of non-pregnant sheep is discussed.

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