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Kahn & Baker (1964) and Kahn, Baker & Zanotti (1965) have shown that norethynodrel induces mammary gland proliferation in rats comparable to that in pregnancy. The major ovarian effect appears to be reduction in weight (Saunders & Drill, 1958; Lakshman & Nelson, 1963), while observations on ovarian histology are less consistent (Holmes & Mandl, 1962; Baker, Kahn & Besemer, 1965). Baker, Kahn, Zanotti & Headings (1966) have recently found adrenocortical hypertrophy as a response to norethynodrel, but other investigators have reported variable effects on adrenal weight (Holmes & Mandl, 1962; Edgren, Hambourger & Calhoun, 1959). Some studies of the effects of this steroid on hypophysial weight and histology showed no alterations (Lakshman & Nelson, 1963; Saunders, 1964), although Holmes & Mandl (1962) observed an increased weight with depletion of basophils and an increase in chromophobes. Since changes in thyroid function can influence other endocrine factors, the effects of norethynodrel in