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The induction of premature metamorphosis in tadpoles by the administration of thyroid preparations, first shown by Gudernatsch [1914], has been studied from various aspects in a number of Anura, most commonly in one or other species of Rana. Morse [1914] and Rogoff & Marine [1917] noted the reaction of R. pipiens tadpoles to thyroid and other substances, and found that a similar effect could be produced by iodinated blood protein. Lenhart [1915] suggested that the tadpole response could be used for biological assay. Romeis [1923] studied the reaction of tadpoles to thyroxine and di-iodotyrosine in some detail and noted the minimal active doses. Blacher [1928] and Allen [1932], working respectively with tadpoles of Rana and of Bufo, studied the sequence of response of different organs to thyroxine. Alphonse & Baumann [1935] found that Rana temporaria tadpoles with back legs 2 mm. in length responded very rapidly to thyroxine. Kaer [1934]