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In the course of a series of dissections, it was noted that the pH of the stomach contents of adrenalectomized rats was uniformly roughly neutral. This finding suggests that adrenalectomy involves an interference in gastric secretion. There is extant a considerable literature on the relation of the adrenal cortex and the processes of resorption, though little is known concerning the possible relation of the adrenal cortex and the processes of secretion. The present paper describes an investigation of the effect of adrenalectomy on gastric secretion.

METHODS: Male rats weighing 110–140 g. were used. Adrenalectomy was performed under ether narcosis. The adrenalectomized animals received Rubin-Krick solution to drink instead of water, and a daily subcutaneous injection of 2 ml. of a solution of 1·4 % NaCl + 0·6 % NaHCO₃. The stomach contents were examined 2–5 days after operation. Animals intended for examination received no food during the preceding night but were