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The metabolic clearance rates, distribution volumes and half-lives of pregnenolone, 17-acetoxypregnenolone and their sulphate esters were determined in man and in the rabbit.

Pregnenolone was cleared about three times more quickly than pregnenolone sulphate in both species.

The metabolic clearance rate of 17-acetoxypregnenolone sulphate is greater in the rabbit than in man, whether expressed in absolute terms or in relation to the metabolic clearance rate of the free steroid.

The slow clearance rate of 17-acetoxypregnenolone sulphate in man is similar to that of testosterone sulphate, dehydroepiandrosterone sulphate and cholesterol sulphate; but is unlike that of pregnenolone sulphate, which is cleared approximately ten times as quickly.

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