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When hamster adrenal tissue is incubated in Krebs—Ringer solution, cortisone is the major steroid product both from endogenous precursors and from added [4-¹⁴C]progesterone (Whitehouse, Vinson & Janssens, 1966, 1967); added radioactive cortisol is rapidly converted into cortisone by hamster adrenal tissue in vitro although cortisol appears to be the main hormonal steroid of the adrenal venous blood. Whole blood of the hamster shows some capacity to reduce cortisone to cortisol, but this seems insufficient to account for the relatively lower yields of cortisone obtained when adrenal tissue is incubated with [4-¹⁴C]progesterone in hamster whole blood. Consequently it may be assumed that the function of the adrenal enzymes is modified by factors in the blood.

The metabolic pathway of progesterone involves the stages: progesterone (intermediates) cortisol cortisone, and hence it is possible that the relative amounts of labelled cortisol and cortisone change throughout the