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For many years rat liver slices have been used in studies on the effect of corticosteroids in vitro, and the assumption has often been made that the biochemical response of cells in slices is the same as that in the intact animal. This applies particularly to the demonstration of an increased synthesis of carbohydrate with steroids of the cortisol/corticosterone type (Chui, 1950; Haynes, 1962; Azuma & Eisenstein, 1964). However, the biochemical properties of isolated cells may differ in several respects from those in intact tissues. In this respect, the usefulness of liver slices in studying gluconeogenesis has been questioned (Krebs, Notton & Hems, 1966). The following results show that the increased glucose synthesis which occurs in response to the addition of cortisol to rat liver slices is not a feature of the liver from an animal in which glycogen synthesis has been stimulated by an injection of cortisol.

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