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The influence of the adenohypophysis and its hormones in liver carcinogenesis has been fairly well established (Korteweg & Thomas, 1939; Moon, Simpson, Li & Evans, 1951; Griffin, Rinfret & Corsigilia, 1953). The carcinogenic agent employed was p-dimethylaminoazobenzene (DAB) or one of its methylated derivatives. Brown (1954) replaced the unsubstituted ring of DAB by pyridine and pyridine-N-oxide rings and thus obtained a number of compounds with varying degrees of carcinogenic activity. In a later study Hamdan (1959) investigated the isomeric p-dimethylaminoazoquinolines and p-dimethylaminoazoisoquinolines, as well as their corresponding N-oxides. He attached the azo-linkage to either pyridine or benzene rings of the quinoline and isoquinoline nucleus and thereby prepared pyrido analogues of DAB or benzo analogues of the pyridine azo dyes.

Although many of these quinoline and isoquinoline azo dyes are more potent in causing hepatic carcinomas than DAB (Hamdan, 1959), the influence of endocrine glands