HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by WHITEHOUSE, B. J. Articles by JANSSENS, P. A. Search for Related Content PubMed Articles by WHITEHOUSE, B. J. Articles by JANSSENS, P. A.

Incubation of hamster adrenal tissue in Krebs bicarbonate Ringer solution gave rapid conversion of added [4-¹⁴C]cortisol to cortisone. Moreover, incubation in Ringer solution with [4-¹⁴C]progesterone as precursor invariably yielded cortisone in greater amounts than cortisol. On the other hand it has been confirmed that cortisol is the major free ultraviolet absorbing steroid in the adrenal venous blood of the hamster. Incubation of adrenal tissue with [4-¹⁴C]progesterone in hamster whole blood gave relatively greater amounts of cortisol which were more in keeping with the findings in vivo. This suggested that the blood contains factors which affect the cortisone-cortisol equilibrium by modifying adrenal enzyme activity. Some reduction of [³H] cortisone to cortisol was also observed during incubation with blood alone.