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The capacity of the liver of the infantile female rat to inactivate oestradiol has been tested by comparison of the effect on the weight of the uterus of β-oestradiol implanted into the spleen or kidney of spayed litter-mate females. Sham-operated, spayed and initial controls were also used. The operations were carried out at daily intervals between 21 and 55 days of age and the animals were killed 5 days later.

As shown by low uterine weights β-oestradiol carried to the liver from the spleen was inactivated at all ages studied.

This result differs from that obtained in previous work employing autotransplants of ovarian tissue to the spleen or kidney and it is suggested that the metabolism of oestradiol differs from that of the hormones secreted by ovary of the prepubertal rat. The spectrum of steroids released before puberty may not be the same as that produced after sexual maturation.