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In intact and orchidectomized animals testosterone had no effect on the reticulo-endothelial system (RES) when administered alone; it potentiated the stimulant effect of 17β-oestradiol on the RES, but had no effect on the RE stimulation produced by diethylstilboestrol. Progesterone was a mild RE stimulant; it had no effect on the RE stimulation produced by 17β-oestradiol or diethylstilboestrol.

Both testosterone and oestrogen caused weight increase in the levator ani of orchidectomized animals; progesterone had no effect. Testosterone and progesterone had no effect on the myotrophic action of 17β-oestradiol, but both compounds inhibited the myotrophic effect of diethylstilboestrol.

The results show that in the male, as in the female, the action of oestrogen on the RES is independent of its action on the reproductive tract, although these two biological activities are contained in the same molecule.