HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by ADESANYA, T. Articles by SHIMA, K. Search for Related Content PubMed PubMed Citation Articles by ADESANYA, T. Articles by SHIMA, K.

The occurrence of insulin in the developing human pancreatic islet was investigated histochemically and by immunoassay. A parallel histochemical study of enzymes in each foetal pancreas was also made.

Oxidative enzymes and the phosphatases, glucose-6-phosphatase and acid phosphatase were localized in pancreatic islet cells from foetuses of 80 mm. crown-rump (CR) length onwards.

Insulin was demonstrated both by the fluorescent antibody technique and by immunoassay in the pancreatic extracts of all foetuses of over 80 mm. CR length. No insulin was present in the extract of the pancreas of a 35 mm. foetus. Since β-granulation occurred in foetuses of 90–110 mm. CR length it became obvious that insulin formation starts before β-granulation.

This article has been cited by other articles:

				D Gu and N Sarvetnick Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice Development, January 5, 1993; 118(1): 33 - 46. [Abstract] [PDF]

				A. E. De Los Monteros, S. G. Driscoll, and J. Steinke Insulin Release from Isolated Human Fetal Pancreatic Islets Science, May 29, 1970; 168(3935): 1111 - 1112. [Abstract] [PDF]