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(1) Testosterone, progesterone, oestriol, 17
-ethynyl-19-nortestosterone and MER-25 were shown to inhibit the vaginal smear response and the uterine growth response to 17β-oestradiol and diethylstilboestrol.
(2) Testosterone potentiated the stimulant effect of 17β-oestradiol on the reticulo-endothelial system (RES); but had no effect on the RE stimulation produced by diethylstilboestrol.
(3) Progesterone had no effect on RE stimulation produced by 17β-oestradiol or diethylstilboestrol.
(4) Oestriol and 17
-ethynyl-19-nortestosterone had no effect on RE stimulation produced by 17β-oestradiol; but both compounds inhibited the stimulant effect of diethylstilboestrol on the RES.
(5) MER-25 inhibited RE stimulation produced by both 17β-oestradiol and diethylstilboestrol.
(6) The effect of anti-oestrogens on oestrogen-produced RE stimulation was shown to depend on the nature of the stimulating oestrogen used.
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