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Journal of Endocrinology (1966) 34, 377-386       DOI: 10.1677/joe.0.0340377
© 1966 Society for Endocrinology
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THE EFFECT OF VARIOUS ANTI-OESTROGENIC COMPOUNDS ON THE RETICULO-ENDOTHELIAL SYSTEM AND REPRODUCTIVE TRACT IN THE OVARIECTOMIZED MOUSE

T. NICOL, B. VERNON-ROBERTS and D. C. QUANTOCK

(1) Testosterone, progesterone, oestriol, 17{alpha}-ethynyl-19-nortestosterone and MER-25 were shown to inhibit the vaginal smear response and the uterine growth response to 17β-oestradiol and diethylstilboestrol.

(2) Testosterone potentiated the stimulant effect of 17β-oestradiol on the reticulo-endothelial system (RES); but had no effect on the RE stimulation produced by diethylstilboestrol.

(3) Progesterone had no effect on RE stimulation produced by 17β-oestradiol or diethylstilboestrol.

(4) Oestriol and 17{alpha}-ethynyl-19-nortestosterone had no effect on RE stimulation produced by 17β-oestradiol; but both compounds inhibited the stimulant effect of diethylstilboestrol on the RES.

(5) MER-25 inhibited RE stimulation produced by both 17β-oestradiol and diethylstilboestrol.

(6) The effect of anti-oestrogens on oestrogen-produced RE stimulation was shown to depend on the nature of the stimulating oestrogen used.







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