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The results of a previous study (Yamashita, 1965) indicated that rutin antagonizes the action of progesterone on the endometrium of the rabbit. This was demonstrated by quantitative measurement of endometrial carbonic anhydrase activity (Miyake & Pincus, 1958 b; Yamashita & Kurouji, 1961 a, b). Since rutin is a flavonoid glucoside, it seemed desirable to investigate the antagonistic action of other flavonoid compounds. The following compounds were used: hesperidin (3',5,7-trihydroxy-4'-methoxyflavanone-7-rutinoside), morin (2',3,4',5,7-pentahydroxyflavone) and quercetin (3,3',4',5,7-pentahydroxyflavone).

The methods used were identical with those described previously (Kurouji, 1963; Yamashita, 1965). Using a modified Clauberg method (1930), rabbits (weighing approximately 1·5 kg.) were primed with oestrogen and received a standard dose of 2 mg. progesterone; simultaneously one of the test compounds was administered either subcutaneously or orally in logarithmically spaced doses of 0·001–100 mg./animal to groups of five rabbits.