HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by KING, R. J. B. Articles by INMAN, D. R. Search for Related Content PubMed PubMed Citation Articles by KING, R. J. B. Articles by INMAN, D. R.

The radioactive material in rat pituitary, liver and uterus 1 hr. after the s.c. injection of either 0·73 or 7·3 µg. [6,7-³H]oestradiol has been investigated. Oestrone and oestradiol were the only compounds detected in pituitary and uterus whereas at least six compounds were present in liver.

Cell fractionation studies have been carried out on anterior pituitary and liver from female rats which had received an injection of either 0·73 or 7·3 µg. [6,7-³H]oestradiol in vivo. Most of the tritium in the anterior pituitary was associated with the nuclear fraction whereas most of the tritium in the liver was in the soluble fraction. The uptake of [6,7-³H]oestradiol by the anterior pituitary reached a maximum -1 hr. after injection of the steroid and remained at this level for the next 3 hr. The intracellular distribution of this steroid at different times after injection suggests that the steroid passes into the cytoplasm and then into the nucleus.

This article has been cited by other articles:

				W. W. Leavitt, J. P. Friend, and J. A. Robinson Estradiol: Specific Binding by Pituitary Nuclear Fraction in vitro Science, August 1, 1969; 165(3892): 496 - 498. [Abstract] [PDF]