HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: JOE-09-0242v1 204/2/105    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Google Scholar Articles by Maggiolini, M. Articles by Picard, D. PubMed PubMed Citation Articles by Maggiolini, M. Articles by Picard, D.

Department of Pharmaco-Biology, University of Calabria, 87030 Rende, Italy
¹ Département de Biologie Cellulaire, Université de Genève, Sciences III, 30, quai Ernest-Ansermet, CH - 1211 Genève 4, Switzerland

(Correspondence should be addressed to M Maggiolini; Email: marcellomaggiolini{at}yahoo.it; D Picard; Email: didier.picard{at}unige.ch)

Steroid hormones such as estrogens are known to signal through ligand-regulated transcription factors of the nuclear receptor superfamily. In addition, they elicit rapid nongenomic responses from membrane-associated receptors. One of these receptors belongs to an entirely different family of proteins. The G protein-coupled and seven-transmembrane receptor, GPR30, is now widely recognized as an estrogen receptor (ER), hence its official new acronym GPER. It appears to mediate a wide range of responses to estrogen in a large variety of cell types. Its functions are clearly distinct from those of the classical nuclear ERs, although these pathways may overlap and interact in some cases. Here, we review the history of the discovery of this new ER, the evidence for the claim that it is an ER, its signal transduction, and its potential functions in physiology and disease.

This article has been cited by other articles:

				Y. Li, L. Birnbaumer, and C. T. Teng Regulation of ERR{alpha} Gene Expression by Estrogen Receptor Agonists and Antagonists in SKBR3 Breast Cancer Cells: Differential Molecular Mechanisms Mediated by G Protein-Coupled Receptor GPR30/GPER-1 Mol. Endocrinol., May 1, 2010; 24(5): 969 - 980. [Abstract] [Full Text] [PDF]