HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: JOE-09-0262v1 204/1/13    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by de Lloyd, A. Articles by Ludgate, M. Search for Related Content PubMed PubMed Citation Articles by de Lloyd, A. Articles by Ludgate, M.

¹ , Centre for Endocrine and Diabetes Sciences
² Department of Child Health, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK

(Correspondence should be addressed to M Ludgate; Email: ludgate{at}cf.ac.uk)

^* (A de Lloyd and J Bursell contributed equally to this work)

The impacts of hyper and hypothyroidism on body composition, i.e. the relative quantity and quality of bone, adipose tissue and muscle, have traditionally been attributed uniquely to abnormal levels of free thyroid hormones. The presence of biologically active TSH receptors in bone, fat and muscle, raises the possibility that both thyroid hormones and TSH contribute to the changes in body composition associated with thyroid disease. This review evaluates the evidence for this in terms of the in vitro experimental approaches applied, data from in vivo sources (i.e. mouse models) and patient-based studies.