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This Article Full Text Full Text (PDF) All Versions of this Article: JOE-09-0190v1 JOE-09-0190v2 203/3/357    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Ueda, S.-y. Articles by Fujimoto, S. PubMed PubMed Citation Articles by Ueda, S.-y. Articles by Fujimoto, S.

Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

(Correspondence should be addressed to T Yoshikawa; Email: tkhr6719{at}med.osaka-cu.ac.jp)

There is growing interest in the effects of exercise on plasma gut hormone levels and subsequent energy intake (EI) but the effects of mode and exercise intensity on anorectic hormone profiles on subsequent EI remain to be elucidated. We aimed to investigate whether circulating peptide YY_3–36 (PYY_3–36) and glucagon-like peptide-1 (GLP-1 or GCG as listed in the HUGO Database) levels depend on exercise intensity, which could affect subsequent EI. Ten young male subjects (mean±S.D., age: 23.4±4.3 years, body mass index: 22.5±1.0 kg/m², and maximum oxygen uptake (VO_{2 max}): 45.9±8.5 ml/kg per min) received a standardized breakfast, which was followed by constant cycling exercise at 75% VO_{2 max} (high intensity session), 50% VO_{2 max} (moderate intensity session), or rest (resting session) for 30 min. At lunch, a test meal was presented, and EI was calculated. Blood samples were obtained during three sessions for measurements of glucose, insulin, PYY_3–36, and GLP-1, which includes GLP-1 (7–36) amide and GLP-1 (9–36) amide. Increases in blood PYY_3–36 levels were dependent on the exercise intensity (effect of session: P<0.001 by two-way ANOVA), whereas those in GLP-1 levels were similar between two different exercise sessions. Of note, increase in area under the curve values for GLP-1 levels was negatively correlated with decrease in the EI in each exercise session (high: P<0.001, moderate: P=0.002). The present findings raise the possibility that each gut hormone exhibits its specific blood kinetics in response to two different intensities of exercise stimuli and might play differential roles in regulation of EI after exercise.