HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: JOE-08-0526v1 201/1/1    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Hoffman, B. G Articles by Jones, S. J M Search for Related Content PubMed PubMed Citation Articles by Hoffman, B. G Articles by Jones, S. J M

Department of Cancer Endocrinology, BC Cancer Research Center, 675 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3¹ Micheal Smith Genome Sciences Centre, BC Cancer Agency, Suite 100-570 West 7th Avenue, Vancouver, BC, Canada V5Z 4S6

(Correspondence should be addressed to S J M Jones; Email: sjones{at}bcgsc.ca)

The transcriptional networks underlying mammalian cell development and function are largely unknown. The recently described use of flow cell sequencing devices in combination with chromatin immunoprecipitation (ChIP-seq) stands to revolutionize the identification of DNA–protein interactions. As such, ChIP-seq is rapidly becoming the method of choice for the genome-wide localization of histone modifications and transcription factor binding sites. As further studies are performed, the information generated by ChIP-seq is expected to allow the development of a framework for networks describing the transcriptional regulation of cellular development and function. However, to date, this technology has been applied only to a small number of cell types, and even fewer tissues, suggesting a huge potential for novel discovery in this field.

This article has been cited by other articles:

				K J Dudley, K Revill, R N Clayton, and W E Farrell Pituitary tumours: all silent on the epigenetics front J. Mol. Endocrinol., June 1, 2009; 42(6): 461 - 468. [Abstract] [Full Text] [PDF]