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This Article Full Text Full Text (PDF) All Versions of this Article: JOE-08-0354v1 199/3/399    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Caricilli, A. M Articles by Saad, M. J A PubMed PubMed Citation Articles by Caricilli, A. M Articles by Saad, M. J A

Department of Internal Medicine, State University of Campinas, 13081-970 Campinas, SP, Brazil

(Correspondence should be addressed to M J A Saad who is now at Departamento de Clínica Médica, FCM-UNICAMP, Cidade Universitária Zeferino Vaz, 13081-970 Campinas, SP, Brazil; Email: msaad{at}fcm.unicamp.br)

The aims of the present study were to investigate the expression of toll-like receptor 2 (TLR2) in muscle and white adipose tissue (WAT) of diet-induced obesity (DIO) mice, and also the effects of its inhibition, with the use of TLR2 antisense oligonucleotide (ASON), on insulin sensitivity and signaling. The expression of TLR2 was increased in muscle and WAT of DIO mice, compared with those that received standard chow. Inhibition of TLR2 in DIO mice, by TLR2 ASON, improved insulin sensitivity and signaling in muscle and WAT. In addition, data show that the inhibition of TLR2 expression prevents the activation of IKBKB, MAPK8, and serine phosphorylation of IRS1 in DIO mice, suggesting that TLR2 is a key modulator of the crosstalk between inflammatory and metabolic pathways. We, therefore, suggest that a selective interference with TLR2 presents an attractive opportunity for the treatment of insulin resistance in obesity and type 2 diabetes.