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In vivo Pharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
¹ Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
² Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

(Requests for offprints should be addressed to K Fosgerau; Email: kf{at}rheoscience.com)

Lipid accumulation in non-adipose tissues is strongly associated with the metabolic syndrome, possibly due to aberrant partitioning of intracellular fatty acids between storage and oxidation. In the present study, we administered the non-metabolizable fatty acid analog [9,10-³H]-(R)-2-bromopalmitate, and authentic ¹⁴C-palmitate to conscious rats, in order to directly examine the initial intracellular fate of fatty acids in a range of insulin-sensitive tissues, including white and red muscles, liver, white adipose tissue, and heart. Rats were studied after administration of an oral glucose load to examine the effect of physiological elevation of glucose and insulin. The tracer results showed that glucose administration partitioned fatty acid toward storage in white muscle (storage:uptake ratios, vehicle vs glucose; 0.64 ± 0.02 vs 0.92 ± 0.09, P < 0.05), and in liver (0.66 ± 0.07 vs 0.98 ± 0.04, P < 0.05), but not in red muscle (1.18 ± 0.07 vs 1.36 ± 0.11, P = not significant). These results demonstrate the physiological relevance of the so-called ‘reverse’ Randle cycle, but surprisingly show that it may be more important in white rather than oxidative red muscle.