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¹ Divisions of Neuroscience and Reproductive Sciences, Oregon National Primate Research Center and
² Departments of Physiology and Pharmacology and
³ Cell and Developmental Biology, Oregon Health and Science University, 505 NW 185th Ave., Beaverton, OR 97006, USA

(Requests for offprints should be addressed to P M Conn; Email: connm{at}ohsu.edu)

The great writer and polyglot, W Somerset Maugham said, ‘I’ll give you my opinion of the human race in a nutshell...their heart’s in the right place, but their head is a thoroughly inefficient organ.’ If his words are applied to trafficking of the human pituitary gonadotropin-releasing hormone receptor, it turns out that he was more right than he knew. Paradoxically, the inefficiency of receptor trafficking to the plasma membrane can bring regulatory advantages to cells. Understanding the mechanism by which cells recognize correctly folded proteins in health and disease opens doors to new therapeutic approaches and provides a more accurate view of mechanisms of normal cell function than is presently available.

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				P. M. Conn, A. Ulloa-Aguirre, J. Ito, and J. A. Janovick G Protein-Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo Pharmacol. Rev., September 1, 2007; 59(3): 225 - 250. [Abstract] [Full Text] [PDF]