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Journal of Endocrinology (2005) 187, 327-332       DOI: 10.1677/joe.1.06426
© 2005 Society for Endocrinology
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STARLING REVIEW

    

MicroRNAs and endocrine biology

Trinna L Cuellar and Michael T McManus

UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, California 94122-0534, USA

(Requests for offprints should be addressed to M T McManus; Email: mmcmanus{at}diabetes.ucsf.edu)

microRNAs (miRNAs) are highly conserved, non-coding RNAs that powerfully regulate gene expression at the post-transcriptional level. These fascinating molecules play essential roles in many biological processes in mammals, including insulin secretion, B-cell development, and adipocyte differentiation. This review provides a general background regarding current knowledge about miRNA biogenesis and the potential contributions of these RNAs to endocrine function.




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