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Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
¹ The Rolf Luft Centre for Diabetes Research, Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institute and Hospital, Stockholm, Sweden

(Requests for offprints should be addressed to Leif Jansson, Department of Medical Cell Biology, Biomedical Centre, Box 571, SE-751 23 Uppsala, Sweden; Email: Leif.Jansson{at}medcellbiol.uu.se)

(Annika M Svensson is currently at Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA)

The effects of a 60% partial pancreatectomy were studied in hyperglycemic GK (Goto–Kakizaki) rats. Partial pancreatectomy or a sham operation was performed on 12-week-old female Wistar rats, GK rats or hybrids between male GK rats and female Wistar rats. Measurements of pancreatic blood flow and islet blood flow were performed by a microsphere technique 2 weeks after surgery. Glucose tolerance was decreased in hybrid compared with Wistar rats, and in GK rats compared with both hybrid and Wistar rats before surgery. Partial pancreatectomy induced minor changes in glucose tolerance. Wistar rats had a decreased islet mass following partial pancreatectomy. Both hybrid and GK rats showed a significant decrease in relative islet volume, but only GK rats in total islet mass, compared with Wistar rats 2 weeks after surgery. Pancreatic blood flow and islet blood flow did not significantly differ between sham-operated Wistar, hybrid or GK rats. After partial pancreatectomy, islet blood flow in relation to islet mass increased 3-fold in Wistar rats and 2-fold in hybrid rats. In contrast, GK rats showed no increase in islet blood flow following partial pancreatectomy. It is concluded that compensatory mechanisms after partial pancreatectomy are operating less effciently in hybrid and GK rats.