JOE Society for Endocrinology Archive
HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

DOI: 10.1677/joe.0.1810297
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (19)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilsey, J
Right arrow Articles by Scarpace, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilsey, J
Right arrow Articles by Scarpace, P.
Journal of Endocrinology, Vol 181, Issue 2, 297-306
Copyright © 2004 by Society for Endocrinology

Articles

Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression

J Wilsey and PJ Scarpace


The objectives of this study were to determine if reduced long-form leptin receptor (ObRb) expression in diet-induced obese (DIO) animals is associated with deficits in maximal leptin signaling and, secondly, to establish the effects of short-term caloric restriction (CR) on ObRb expression and function. Groups of DIO and life-long chow-fed (CHOW) F344xBN male rats, aged 6 months, were given an i.c.v. injection containing 2 micro g leptin or artificial cerebrospinal fluid (ACSF) vehicle. Leptin induced a >6-fold increase in STAT3 phosphorylation in CHOW rats, but less than 2-fold increase in DIO. Reduced maximal leptin-stimulated STAT3 phosphorylation in DIO rats was coupled with a decline in both ObRb expression and protein. At this point, subgroups of DIO and CHOW animals underwent CR for 30 days and were then tested for acute leptin responsiveness. CR resulted in a 45 and 85% increase respectively in leptin-stimulated STAT3 phosphorylation in CHOW and DIO animals. Similarly, CR increased ObRb expression and protein in both CHOW and DIO animals. To explore the role of leptin in regulating ObRb expression, we reversibly overexpressed leptin in the hypothalamus and found that ObRb mRNA inversely follows central leptin expression. By enhancing both ObRb expression and signaling capacity, CR may enhance leptin responsiveness in leptin-resistant DIO animals.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. R. Thorn, R. A. Ehrhardt, W. R. Butler, S. M. Quirk, and Y. R. Boisclair
Insulin regulates hepatic leptin receptor expression in early lactating dairy cows
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1455 - R1462.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. S. Martin, A. Qasim, and M. P. Reilly
Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease
J. Am. Coll. Cardiol., October 7, 2008; 52(15): 1201 - 1210.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. Shapiro, M. Matheny, Y. Zhang, N. Tumer, K.-Y. Cheng, E. Rogrigues, S. Zolotukhin, and P. J. Scarpace
Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-Resistant Rats
Diabetes, March 1, 2008; 57(3): 614 - 622.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. A. Augustine, S. R. Ladyman, and D. R. Grattan
From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy
J. Physiol., January 15, 2008; 586(2): 387 - 397.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. E. Cohen, E. Kokkotou, S. B. Biddinger, T. Kondo, R. Gebhardt, J. Kratzsch, C. S. Mantzoros, and C. R. Kahn
High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice
J. Biol. Chem., August 10, 2007; 282(32): 23672 - 23678.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
P. J. Scarpace, M. Matheny, Y. Zhang, K.-Y. Cheng, and N. Tumer
Leptin Antagonist Reveals an Uncoupling between Leptin Receptor Signal Transducer and Activator of Transcription 3 Signaling and Metabolic Responses with Central Leptin Resistance
J. Pharmacol. Exp. Ther., February 1, 2007; 320(2): 706 - 712.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Zhang, M. K. Matheny, N. Tumer, M. K. Mitchell, and P. J. Scarpace
Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R868 - R874.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. L. Martin, T. Alquier, K. Asakura, N. Furukawa, F. Preitner, and B. B. Kahn
Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle
J. Biol. Chem., July 14, 2006; 281(28): 18933 - 18941.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Dagon, Y. Avraham, I. Magen, A. Gertler, T. Ben-Hur, and E. M. Berry
Nutritional Status, Cognition, and Survival: A NEW ROLE FOR LEPTIN AND AMP KINASE
J. Biol. Chem., December 23, 2005; 280(51): 42142 - 42148.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M.-y. Wang, L. Orci, M. Ravazzola, and R. H. Unger
Fat storage in adipocytes requires inactivation of leptin's paracrine activity: Implications for treatment of human obesity
PNAS, December 13, 2005; 102(50): 18011 - 18016.
[Abstract] [Full Text] [PDF]


HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Society for Endocrinology.